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. 2018 May 10;37:102. doi: 10.1186/s13046-018-0754-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Screening for potential hypermethylated genes in NPC. The Venn diagram indicates intersected 326 genes that are both hypermethylated in NPC cells with relative methylated DNA enrichment ≥1.5-fold in C666.1 compared with that of NP69 (1161 genes) and downregulated at least 1.3-fold in nine NPC tumors (T) compared with pooled adjacent normal tissues (N) (8447 genes). The intersected genes were analyzed by MetaCore™ GeneGo pathway analysis. The top three significant pathways are listed. The bottom table shows the relative methylated DNA enrichment and the expression fold-change of the four genes involved in the tight junction pathway