Table 3.
Least squares (LS) means scoresa (95% Confidence intervals, CIs) of HRQoL according to quartiles of Healthy dietary pattern in breast cancer survivors
| Quartiles of the Healthy dietary pattern | ||||||
|---|---|---|---|---|---|---|
| Variables | N (=232) | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P for trend |
| EORTC QLQ - C30 | ||||||
| Global health status/QoL | 220 | 40.41 (28.37 - 57.55) | 37.47 (27.10 - 51.81) | 39.93 (28.92 - 55.14) | 30.00 (20.83 - 43.21) | 0.31 |
| Functioning | ||||||
| Physical Functioning | 228 | 76.21 (67.82 - 85.65) | 79.02 (71.09 - 87.85) | 77.80 (69.85 - 86.65) | 71.45 (63.52 - 80.37) | 0.45 |
| Role Functioning | 229 | 62.82 (49.32 - 80.02) | 77.50 (61.80- 97.17) | 69.47 (55.05 - 87.66) | 65.77 (51.12 - 84.62) | 0.84 |
| Emotional Functioning | 230 | 76.24 (63.16 - 92.04) | 72.09 (60.45 - 85.96) | 60.42 (50.51 - 72.26) | 71.77 (58.99 - 87.32) | 0.31 |
| Cognitive Functioning | 230 | 74.53 (65.00 - 85.44) | 78.52 (69.10 - 89.22) | 73.09 (64.18 - 83.23) | 70.66 (61.28 - 81.47) | 0.48 |
| Social Functioning | 230 | 57.8 (45.69 - 73.12) | 63.28 (50.80 - 78.84) | 60.55 (48.42 - 75.72) | 62.67 (49.05 - 80.05) | 0.66 |
| Symptom | ||||||
| Fatigue | 229 | 27.26 (19.48 - 38.15) | 20.26 (14.88 - 27.58) | 22.61 (16.52 - 30.94) | 23.51 (16.68 - 33.13) | 0.55 |
| Nausea and vomiting | 230 | 4.00 (2.48 - 6.44) | 2.24 (1.44 - 3.49) | 3.71 (2.36 - 5.83) | 3.17 (1.93 - 5.21) | 0.73 |
| Pain | 229 | 9.84 (5.80 - 16.71) | 6.13 (3.77 - 9.97) | 11.13 (6.79 - 18.24) | 10.64 (6.20 - 18.28) | 0.53 |
| Dyspneab,c | 228 | 8.86 (5.05 - 15.52) | 4.21 (2.52 - 7.03) | 4.75 (2.82 - 8.01) | 2.87 (1.62 - 5.08) | 0.005 |
| Insomniab,c | 228 | 11.46 (6.59 - 19.95) | 12.11 (7.28 - 20.15) | 20.41 (12.15 - 34.26) | 29.77 (16.87 - 52.51) | 0.005 |
| Loss of appetite | 228 | 3.00 (1.74 - 5.15) | 3.66 (2.23 - 6.02) | 2.65 (1.60 - 4.39) | 3.32 (1.91 - 5.79) | 0.99 |
| Constipation | 228 | 4.25 (2.40 - 7.54) | 5.69 (3.36 - 9.63) | 7.01 (4.10 - 11.99) | 4.18 (2.32 - 7.50) | 0.78 |
| Diarrhea | 230 | 3.04 (1.82 - 5.08) | 2.47 (1.53 - 3.99) | 2.76 (1.70 - 4.51) | 1.79 (1.05 - 3.05) | 0.18 |
| Financial impact | 230 | 7.34 (4.12 - 13.07) | 4.51 (2.63 - 7.74) | 9.47 (5.47 - 16.40) | 9.61 (5.27 - 17.53) | 0.27 |
| EORTC QLQ-BR23 | ||||||
| Functioning | ||||||
| Body image | 229 | 40.11 (27.32 - 58.88) | 33.23 (23.21 - 47.59) | 40.56 (28.06 - 58.62) | 28.18 (18.89 - 42.03) | 0.30 |
| Sexual functioning | 216 | 2.83 (1.62 - 4.92) | 3.89 (2.32 - 6.52) | 3.93 (2.33 - 6.65) | 3.94 (2.20 - 7.08) | 0.33 |
| Future perspective | 229 | 26.93 (15.91 - 45.58) | 20.85 (12.74 - 34.10) | 21.67 (13.08 - 35.90) | 15.43 (8.92 - 26.70) | 0.14 |
| Symptom | ||||||
| Systematic therapy side effects | 230 | 23.34 (17.37 - 31.37) | 15.01 (11.39 - 19.79) | 22.47 (16.96 - 29.76) | 25.97 (19.09 - 35.33) | 0.39 |
| Breast symptoms | 230 | 12.10 (7.66 - 19.11) | 6.96 (4.54 - 10.68) | 10.50 (6.80 - 16.22) | 12.11 (7.52 - 19.49) | 0.84 |
| Arm symptoms | 230 | 20.54 (13.59 - 31.03) | 18.25 (12.41 - 26.84) | 21.70 (14.65 - 32.12) | 31.48 (20.48 - 48.39) | 0.13 |
| Upset by hair loss | 151 | 14.15 (6.70 - 29.89) | 32.78 (15.61 - 68.82) | 23.84 (12.30 - 46.18) | 34.49 (16.45 - 72.32) | 0.11 |
LS means least squares means, 95% CI 95% confidence interval, HRQoL health-related quality of life, EORTC QLQ-C30 European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, BR23 breast cancer module 23
aAdjusted for age at diagnosis (year; continuous), body mass index at diagnosis (kg/m2; continuous), energy intake (kcal/d; continuous), marital status (married or cohabitation, others), education level (high school or below, college or above), physical activity (MET-hr/wk.; continuous), breast cancer stage at diagnosis (I,II,III), time since surgery (months; continuous) and menopausal status at diagnosis (premenopausal, postmenopausal status)
bP value for comparing top with bottom quintiles < 0.05
cFalse Discovery Rate (FDR) < 0.1