Table 1.
Frequency of regional TDP-43 deposition of all 14 regions for each of the original five stages among the 193 cases
| Region | Stage I (N = 34) |
Stage II (N = 48) |
Stage III (N = 59) |
Stage IV (N = 39) |
Stage V (N = 13) |
|---|---|---|---|---|---|
|
| |||||
| Amygdala | 34 (100%) | 48 (100%) | 59 (100%) | 39 (100%) | 13 (100%) |
| Entorhinal | 0 (0%) | 43 (90%) | 58 (98%) | 39 (100%) | 13 (100%) |
| Subiculum | 0 (0%) | 29 (60%) | 57 (97%) | 38 (97%) | 12 (92%) |
| Dentate | 0 (0%) | 0 (0%) | 57 (97%) | 38 (97%) | 13 (100%) |
| OTC | 0 (0%) | 0 (0%) | 53 (90%) | 39 (100%) | 13 (100%) |
| Insula | 0 (0%) | 1 (2%) | 30 (51%) | 24 (63%) | 10 (83%) |
| Ventral striatum | 1 (3%) | 2 (4%) | 24 (41%) | 27 (69%) | 7 (58%) |
| Basal forebrain | 0 (0%) | 0 (0%) | 19 (33%) | 21 (54%) | 12 (92%) |
| Inferior temporal | 0 (0%) | 0 (0%) | 0 (0%) | 39 (100%) | 12 (92%) |
| Substantia nigra | 1 (3%) | 0 (0%) | 10 (17%) | 13 (33%) | 10 (77%) |
| Inferior olive | 1 (3%) | 2 (4%) | 8 (14%) | 7 (18%) | 8 (67%) |
| Midbrain tectum | 0 (0%) | 0 (0%) | 5 (8%) | 10 (26%) | 10 (77%) |
| Basal ganglia | 1 (3%) | 0 (0%) | 0 (0%) | 0 (0%) | 11 (85%) |
| Middle frontal | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 13 (100%) |