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. 2018 Apr 11;159(6):2275–2287. doi: 10.1210/en.2018-00147

Figure 3.

Figure 3.

Dexamethasone treatment reduces fat mass in obese mice. Weekly total (A) body mass and (B) fat mass measures via EchoMRI in mice over the course of treatment (solid lines represent NCD mice, and dashed lines represent HFD mice). (C) Adipose tissue weights in 16-hour–fasted mice following euthanasia. Mice were euthanized at 28 weeks of age following 6 weeks of dexamethasone (NCD, n = 8; HFD, n = 12) or vehicle (NCD, n = 8; HFD, n = 22) treatment and 18 weeks of diet. (D) Food consumption measured weekly over the course of treatment. (E) Amount of dexamethasone consumed per mouse throughout the study normalized to body weight as determined by volume consumed per cage per week for NCD- (n = 12) and HFD-fed (n = 20) mice. (F) Concentration of dexamethasone in serum of NCD-fed (n = 8) and HFD-fed (n = 11) at the end of the study as determined by liquid chromatography–mass spectrometry. Asterisks indicate a statistically significant treatment or diet effect for the pairwise comparison.