Figure 3.

ASCVD events predictable by SCORE. In a large contemporary European cohort of apparently healthy individuals aged 40–75 years at baseline examination (Copenhagen General Population Study, n = 44 889), fatal ASCVD as defined by SCORE constituted only 9% of the hard ASCVD events (fatal coronary heart disease and stroke plus non-fatal myocardial infarction and stroke) observed over ≥5 years of follow-up. Relatively few of the fatal ASCVD events occurred in the target population for SCORE-based risk assessment (age 40–65 years). In the overall population, only 18% of all fatal ASCVD events occurred among those aged 40–65 years at baseline¹⁰. This is too few fatal events to allow for reliable sex-specific recalibration of SCORE in the target population. Adapted from Mortensen et al.¹⁹ ASCVD = atherosclerotic cardiovascular disease.