Table 1.
Demographic and clinical characteristics by treatment group
| Characteristic | Donepezil No. (%) |
Control No. (%) |
|---|---|---|
| Total N | 99 (100) | 99 (100) |
| Age, years | ||
| Median (range) | 56 (19–84) | 54 (19–81) |
| Age ≥50 | 58 (59) | 61 (62) |
| Sex | ||
| Female | 56 (57) | 50 (51) |
| Male | 43 (43) | 49 (49) |
| Race | ||
| Hispanic | 1 (1) | 0 (0) |
| Asian | 1 (1) | 0 (0) |
| African-American | 7 (7) | 9 (9) |
| Non-Hispanic White | 90 (91) | 90 (91) |
| Marital Status* | ||
| Single | 12 (12) | 10 (10) |
| Married/Married-like | 66 (67) | 73 (74) |
| Separated/Divorced/ Widowed | 21 (21) | 15 (15) |
| Education* | ||
| ≤High school graduation | 29 (29) | 33 (34) |
| Vocational / Some college | 39 (39) | 40 (42) |
| College degree or higher | 31 (31) | 23 (24) |
| Income* | ||
| <U.S. $20 K | 31 (36) | 34 (42) |
| U.S. $20–50 K | 31 (36) | 27 (33) |
| U.S. $50+ K | 24 (28) | 20 (25) |
| Work Outside Home* | 28 (28) | 31 (32) |
| Months since Diagnosis | ||
| Median (range) | 37.7 (7.3–298.4) | 39.9 (8.8–423.2) |
| ≥36 months from diagnosis | 51 (52) | 55 (56) |
| Body Mass Index | ||
| Median (range) | 27.2 (17.3–49.4) | 27.9 (18.4–41.1) |
| Underweight and normal, <25 | 36 (36) | 28 (28) |
| Overweight, 25–29.9 | 31 (31) | 36 (36) |
| Obese, ≥30+ | 32 (32) | 35 (35) |
| ECOG Performance Status | ||
| 0 | 49 (49) | 45 (45) |
| 1 | 46 (46) | 48 (48) |
| 2 | 4 (4) | 6 (6) |
| Diagnosis | ||
| Primary brain tumor | 65 (66) | 65 (66) |
| Brain metastasis | 27 (27) | 26 (26) |
| PCI | 7 (7) | 8 (8) |
| Primary Tumor Type (N = 65/group) | ||
| Glioblastoma multiforme | 15 (23) | 8 (12) |
| Anaplastic astrocytoma | 4 (6) | 10 (15) |
| Anaplastic oligodendroglioma | 8 (12) | 8 (12) |
| Anaplastic oligoastrocytoma | 2 (3) | 1 (2) |
| Anaplastic ependymoma | 3 (5) | 1 (2) |
| Anaplastic mixed glioma | 0 (0) | 1 (2) |
| Low-grade astrocytoma | 5 (8) | 1 (2) |
| Low-grade oligodendroglioma | 5 (8) | 8 (12) |
| Low-grade oligoastrocytoma | 0 (0) | 1 (2) |
| Meningioma | 13 (20) | 9 (14) |
| Pilocycstic astrocytoma | 2 (3) | 4 (6) |
| Other | 8 (12) | 13 (20) |
| Metastasis Site (N = 34 per group) | ||
| Lung | 19 (57) | 21 (62) |
| Breast | 9 (27) | 7 (21) |
| Other / Unknown | 6 (18) | 6 (18) |
| Strata | ||
| 1—Whole brain, WFU | 10 (10) | 10 (10) |
| 2—Whole brain, CCOP | 30 (30) | 30 (30) |
| 3—Partial brain, WFU | 30 (30) | 30 (30) |
| 4—Partial brain, CCOP | 29 (29) | 29 (29) |
* Some missing data. Abbreviations: CCOP, Community Clinical Oncology Program sites; ECOG, Eastern Cooperative Oncology Group; K, $1000; PCI, prophylactic cranial irradiation; WFU, Wake Forest University.