Table 1.
Selected biobanks with linked EHRs and genetic data in ≥50 000 participants listed in descending order of sample size with available genetic data
| Cohort | Country | Institution or companya | Cohort sizeb,c | Samples with matched EHR and genetic data availableb,d | Access | References |
|---|---|---|---|---|---|---|
| UK BioBank (UKBB) http://www.ukbiobank.ac.uk | United Kingdom | UK Biobank charity | 500 000 | 488 377 genotyped | Application for bona fide researcher | (9,52) |
| DeCODE Genetics https://www.decode.com | Iceland | Amgen | >350 000 | >350 000 | Contact to collaborate | (4,53,54) |
| Million Veteran Program (MVP) https://www.research.va.gov/mvp/ | USA | Department of Veterans Affairs | >500 000 | >350 000 | Contact to collaborate | (12,13) |
| BioBank Japan Project http://www.pgrn.org/biobank-japan.html | Japan | Pharmacogenomics Research Network | 200 000 | 162 255 genotyped | Contact to collaborate | (34,55) |
| China Kadoorie Biobank http://www.ckbiobank.org/site/ | China | University of Oxford, Chinese Academy of Medical Sciences | 510 000 | >130 000 | Application for bona fide researcher | (56,57) |
| Kaiser Permanente Research Bank https://researchbank.kaiserpermanente.org/ our-research/for-researchers/ | USA | Kaiser Permanente | 270 570 | 102 998 genotyped | Application for bona fide researcher | (7,58) |
| eMerge Network https://emerge.mc.vanderbilt.edu | USA | NHGRI | 105 325 | 83 717 | Application for eMERGE affiliate membership | (6,18) |
| Danish Biobank Register http://www.biobankdenmark.dk | Denmark | Danish National Biobank | 5.7 million | >70 000 | Application for bona fide researcher | (59) |
| Nord Trondelag Health Study (HUNT) https://www.ntnu.edu/hunt | Norway | Norwegian University of Science and Technology | 120 000 | 69 037 genotyped | Application and collaboration with PI affiliated with a Norwegian research institute | (15,60) |
| DiscovEHR http://www.discovehrshare.com | USA | Geisenger Health System, Regeneron Genetics Center | 50 000 | >50 000 exome sequences | Contact to collaborate | (43,61) |
a
Main institution responsible for the resource, many other institutions may provide funding or support.
b
Sample size as of January 2018. In situations where up to date sample sizes were difficult to find, sample sizes from recent publications were used.
c
Unique number of participants with some type of data available (52–61).
d
Actual samples available for analysis may be less due to quality control. Number includes both sequencing and genotyping with the type of data described when possible.