Figure 2.

Effect of ovx on neuritic plaque deposition in the hippocampus of 2×TgAD mice 4G8 immunostaining (a–d, i–l, and q–t) and thioflavin S staining (e–h, m–p, and u–x) were used to detect neuritic plaques in the hippocampus. Black arrows point to plaques. In the WT mice, no plaques were observed, and ovx did not affect neuritic plaque deposition. However, a few neuritic plaques were observed in the brain sections of 1-month and 3-month AD groups. Scale bar: 200 μm.