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The effect of ovx on neuritic plaque deposition in the cortex of 2×TgAD mice 4G8 immunostaining was used to detect neuritic plaques in the cortex. In these 2×TgAD mice, similar results were obtained in the hippocampus. No plaques were observed in the 3-month-old mice (equal to 1 week after ovariectomy). Neuritic plaques were observed in the brain sections of 4-month and 6-month-old mice (equal to 1 month and 3 months after ovariectomy, respectively). Scale bar = 200 μm.
