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Crushed IN and intact oral doses for Part B
| TreatmentSequence | CrushedIN Dose | Oral IntactDose (Capsules) |
|---|---|---|
| A | Placebo powder | Placebo capsules |
| B | Placebo powder | Benzhydrocodone/APAP (at MTD) |
| C | Benzhydrocodone/APAP (at MTD) | Placebo capsules |
| D | Hydrocodone/APAP(at MTD) | Placebo capsules |
| E | Placebo powder | Hydrocodone/APAP(at MTD) |
APAP = acetaminophen; MTD = maximum tolerated dose.
