Figure 2.

Relationships between different pharmacogenomics (PGx) variant resources. PharmGKB manually curates PGx literature and acts as a repository of information about PGx variants. CPIC uses PharmGKB literature and drug label annotations to help rank gene–drug pairs for genotype-based drug prescribing guideline development, and incorporates PhamGKB annotations with independent literature reviews to create the guideline recommendations, that can then be used to support clinical decision making. PharmCAT facilitates genome annotation with actionable PGx information, starting with CPIC guideline recommendations.