Table 3.

Associations Between Levels of Inflammatory Markers and Longitudinal rCBF change

			Coordinate
Marker	Region	Side	x	y	z	t Value	p Value	Voxels
Baseline CRP	Anterior cingulate (32)	R	4	22	−10	−2.62	.001	75
	Hippocampus/Parahippocampal gyrus (36)	L	−28	−24	−20	−2.62	<.001	283
	Brainstem	R	6	−10	−12	−2.62	.003	57
	Putamen	R	28	−10	14	−2.62	<.001	163
Mean CRP	Anterior cingulate (32)	R	10	22	−10	−3.41	<.001	134
	Entorhinal cortex (28)	R	8	6	−26	−3.42	<.001	79
	Putamen	R	28	−4	12	−3.62	<.001	176
	Hippocampus	L	−30	−22	−12	−3.73	<.001	346
	Precuneus (18)*	R	16	−58	24	−3.20	.001	82
	Cerebellum	R	4	−44	−38	−3.25	.001	65
	Brainstem	R	2	−10	−14	−3.48	<.001	84
Baseline IL-6	Medial frontal cortex(10)	R	6	58	16	−2.62	.003	59
	Orbitofrontal cortex (11)	L	-2	24	−24	−2.61	<.001	185
	Superior temporal gyrus (22)	L	−52	0	−6	−2.61	<.001	156
	Hippocampus	L	−30	−30	−8	−2.61	.003	108
	Cuneus(17)	R	4	−74	10	3.26	.004	55
Mean IL-6	Orbitofrontal cortex (25)	L	-4	18	−16	−2.62	.001	137
	Middle temporal gyrus (21)*	L	-46	0	−12	−2.62	<.001	159
	Parahippocampal gyrus (36)	L	−24	−34	−10	−2.62	<.001	152
	Cuneus (17)	R	4	−74	10	3.26	.005	58

Note: Regions where higher levels of baseline and mean CRP and IL-6 were associated with longitudinal changes in rCBF. All regions, with the exception of the cuneus, show a negative correlation where higher markers levels were associated with decreases in rCBF. Stereotaxic coordinates are listed, Brodmann areas are indicated in parentheses

^*indicates regions that did not survive correction for regional tissue volume. CRP = C-reactive protein; IL-6 = Interleukin-6.