Table 1.

Definition of parameters and their estimates for the model describing the relationship between ΔQTcF and upadacitinib plasma concentration

Parameter	Estimate (standard error)	P value
μ: Intercept (overall mean ΔQTcF; msec)	27.9 (14)	0.04
${\text{β}}_1:$ Slope for the effect of baseline QTcF	–0.09 (0.03)	0.01
${\beta }_2:$ Slope for the effect of upadacitinib concentration (msec/ng/mL)	–0.004 (0.007)	0.57
Random subject effect (ω) variance	22.4	—
Residual error (ɛ) variance	30.6	—