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. 2018 Feb 7;145(1):80–89. doi: 10.1111/jnc.14285

Figure 2.

Figure 2

Administration of Cystatin C (CysC) extends the survival time of SOD1G93A mice. (a) Schematic diagram of CysC administration. The osmotic pump was implanted at 100 days of age (around the time of onset of disease). CysC was continuously delivered at 66 ng/day for 4 weeks during the early phase of the disease. (b) Survival curves of the phosphate‐buffered saline (PBS)‐ or CysC‐infused SOD1G93A mouse cohort plotted over time (n = 12 in total, n = 5 in male and n = 7 in female for both groups). The survival data were analyzed by the log‐rank test, and the average survival times are shown with SD.