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. 2018 Feb 5;13(4):312–320. doi: 10.1002/cmdc.201700731

Scheme 2.

Scheme 2

Synthesis of trifluoromethyl derivatives of BC23 (NBC41) and NBC6 (NBC42): a) CF3CN, Zn(acac)2, CH2Cl2, RT, 18 h; b) K2CO3, EtOH, 50 °C, 24 h (for R=Me); c) DPBA, THF, 50 °C, 16 h.