Figure 4.

Models for memory inflation. The original model is based on 2 populations of cells, 1 in lymph nodes and the rest expanded in the periphery. Model 2 includes an intermediate cell type which does not possess lymph node homing markers but retains proliferative capacity. Exposure to antigen on a non‐classical APC in the periphery (at sites to be defined fully in the MCMV and adenovirus models) could drive proliferation and differentiation of these cells. They may also self‐renew or potentially de‐differentiate toward the long‐lived central memory pool