Table 1.
Results of ΔIOP and relative reduction of IOP. Comparison of different regimens using mixed‐comparison model on effect of IOP lowering
| PGA | −6.07 (−8.53, −3.61) | −5.94 (−7.61, −4.27) | −9.10 (−11.55, −6.65) | 3.48 (−1.43, 8.39) | 3.60 (1.47, 5.73) | 2.17 (−1.74, 6.08) | 1.23 (−2.83, 5.29) | −1.95 (−6.91, 3.00) | −1.43 (−3.62, 0.77) | −2.43 (−6.08, 1.23) | −18.55 (−24.39, −12.70) |
| 1.59 (0.98, 2.21) | AA | 0.13 (−2.41, 2.68) | −3.03 (−5.78, −0.28) | 9.55 (4.19, 14.91) | 9.67 (6.60, 12.74) | 8.24 (3.75, 12.73) | 6.68 (1.70, 11.66) | 4.12 (−0.61, 8.84) | 4.64 (1.57, 7.72) | 3.65 (−0.67, 7.96) | −12.47 (−18.82, −6.13) |
| 1.53 (1.11, 1.95) | −0.06 (−0.70, 0.57) | BB | −3.16 (−5.74, −0.58) | 9.42 (4.42, 14.41) | 9.54 (7.24, 11.83) | 8.11 (4.10, 12.11) | 6.54 (1.99, 11.10) | 3.99 (−1.02, 8.99) | 4.51 (2.14, 6.88) | 3.51 (−0.35, 7.38) | −12.61 (−18.69, −6.53) |
| 2.44 (1.82, 3.05) | 0.84 (0.17, 1.52) | 0.91 (0.27, 1.55) | CAI | 12.58 (7.26, 17.90) | 12.70 (9.70, 15.70) | 11.27 (6.84, 15.69) | 9.70 (4.81, 14.59) | 7.15 (2.43, 11.87) | 7.67 (4.81, 10.53) | 6.67 (2.43, 11.87) | −9.45 (−15.79, −3.11) |
| −1.42 (−2.68, −0.16) | −3.01 (−4.39, −1.64) | −2.95 (−4.23, −1.66) | −3.86 (−5.22, −2.49) | PGA + AA | 0.12 (−4.48, 4.72) | −1.31 (5.57, 2.95) | −2.87 (−8.99, 3.24) | −5.43 (−12.29, 1.43) | −4.91 (−9.71, −0.11) | −5.91 (−11.70, −0.11) | −22.02 (−29.66, −14.39) |
| −0.92 (−1.45, −0.40) | −2.52 (−3.28, −1.75) | −2.45 (−3.02, −1.88) | −3.36 (−4.11, −2.61) | 0.50 (−0.70, 1.69) | PGA + BB | −1.43 (−4.80, 1.93) | −3.00 (−7.22, 1.23) | −5.55 (−10.82, −0.29) | −5.03 (−7.27, −2.79) | −6.03 (−9.81, 2.24) | −22.15 (28.37, −15.92) |
| −1.13 (−2.24, −0.01) | −2.72 (−3.96, −1.47) | −2.65 (−3.79, −1.51) | −3.56 (−4.79, −2.33) | 0.29 (−0.72, 1.31) | −0.20 (−1.21, 0.81) | PGA + CAI | −1.56 (−6.91, 3.78) | −4.12 (−10.32, 2.08) | −3.60 (−7.49, 0.29) | −4.59 (−9.59, 0.40) | −20.71 (−27.75, −13.68) |
| −0.34 (−1.35, 0.67) | −1.78 (−3.03, −0.53) | −1.72 (−2.86, −0.57) | −2.62 (−3.85, −1.40) | 1.23 (−0.34, 2.80) | 0.74 (−0.33, 1.81) | 0.94 (−0.52, 2.39) | AA + BB | −2.56 (−9.11, 3.99) | −2.04 (−6.26, 2.19) | −3.03 (−8.44, 2.38) | −19.15 (−26.51, −11.79) |
| 0.57 (−0.69, 1.82) | −1.02 (−2.22, 0.17) | −0.96 (−2.23, 0.31) | −1.87 (−3.06, −0.67) | 1.99 (0.24, 3.74) | 1.49 (0.16, 2.82) | 1.69 (0.04, 3.35) | 0.76 (−0.90, 2.41) | AA + CAI | 0.52 (−4.70, 5.75) | −0.47 (−6.54, 5.59) | −16.59 (−24.26, −8.93) |
| 0.25 (−0.29, 0.79) | −1.34 (−2.10, −0.58) | −1.28 (−1.86, −0.70) | −2.19 (−2.89, −1.48) | 1.67 (0.43, 2.91) | 1.17 (0.61, 1.73) | 1.38 (0.27, 2.49) | 0.44 (−0.63, 1.50) | −0.32 (−1.63, 1.00) | BB + CAI | −1.00 (−4.67, 2.68) | −17.12 (−23.36, −10.87) |
| 0.23 (−0.56, 1.02) | −1.36 (−2.34, −0.38) | −1.30 (−2.16, −0.44) | −2.21 (−3.17, −1.24) | 1.65 (0.22, 3.08) | 1.16 (0.30, 2.01) | 1.36 (0.05, 2.66) | 0.42 (−0.88, 1.72) | −0.34 (−1.80, 1.13) | −0.02 (−0.86, 0.82) | BB + MIO | −16.12 (−23.01, −9.23) |
| 3.60 (2.19, 5.01) | 2.01 (0.47, 3.54) | 2.07 (0.60, 3.54) | 1.16 (−0.37, 2.70) | 5.02 (3.13, 6.91) | 4.52 (3.02, 6.02) | 4.73 (2.93, 6.52) | 3.79 (1.99, 5.59) | 3.03 (1.15, 4.92) | 3.35 (1.84, 4.85) | 3.37 (1.78, 4.98) | PLA |
Treatment.
ΔIOP.
Relative reduction of IOP.
MD indicates mean difference.
AA = α‐2 adrenergic agonist, BB = beta‐blocker, CAI = carbonic anhydrase inhibitors, IOP = intra‐ocular pressure, PGA = prostaglandin analogue, PLA = placebo.