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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Pharmacol Biochem Behav. 2017 Dec 16;165:25–28. doi: 10.1016/j.pbb.2017.12.005

Figure 1. Males are more sensitive than females to the impairing effects of acute nicotine on fear extinction.

Figure 1

Panel A: Acute nicotine impairs extinction at all doses on extinction days 3–5 in male mice (n=7–17 per group). Panel B: Only the highest dose of nicotine impairs extinction in female mice (n=9–25 per group). ~ p =0.05 on t-tests comparing the 0.09 mg/kg to saline. * p < 0.05 on t-tests comparing the 0.18 mg/kg to saline. # p < 0.05 on t-test comparing 0.36 mg/kg nicotine to saline.