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. Author manuscript; available in PMC: 2018 May 11.
Published in final edited form as: Biotechnol Bioeng. 2017 Jun 29;114(10):2379–2389. doi: 10.1002/bit.26345

Figure 4.

Figure 4

SHIELD formation and mechanics. (A) SHIELD is composed of an engineered C7 protein and an 8-arm PEG conjugated with P1 binding peptides. HGFdf is conjugated to the C7 component of SHIELD. SHIELD is formed upon mixing the two components under physiologic conditions. (B–D) Shear-thinning and self-healing capability of SHIELD. The two components were mixed in the barrel of the insulin syringe and allowed to gel. Upon hand-application of a shear force, the solution state reformed and injected through the needle. Almost immediately after, the gel state reformed, demonstrated by (D) flipping the dish upside down.