Skip to main content
. Author manuscript; available in PMC: 2018 May 11.
Published in final edited form as: Bioorg Med Chem. 2015 Dec 1;24(4):521–544. doi: 10.1016/j.bmc.2015.11.045

Scheme 2.

Scheme 2

Alkylation of 6-((2,4-difluorophenyl)sulfonyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (5u). Reagents and conditions: (i) X-I, NaH, DMF, 50 °C, 1 h, 55–60%; (ii) m-CPBA, CH2Cl2, rt, 3 h, 50–60%.