Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In vitro Cytotoxicity and kinase profile of pyrido[2,3-d]pyrimidine (7aw–aai) with variable at C2 position
| |||
|---|---|---|---|
|
| |||
| Compd | Z | IC50 (µM) | |
|
|
|||
| K562 | DU145 | ||
| 7aw |
|
50 | 30 |
| 7ax |
|
0.5 | 0.5 |
| 7ay |
|
15 | 15 |
| 7az |
|
0.75 | 0.75 |
| 7aaa |
|
0.75 | 0.75 |
| 7aab |
|
75 | 100 |
| 7aac |
|
5 | 5 |
| 7aad |
|
30 | 75 |
| 7aae |
|
5 | 5 |
| 7aaf |
|
15 | 100 |
| 7aag |
|
10 | 10 |
| 7aah |
|
5 | 5 |
| 7aai |
|
0.75 | 0.75 |
