Table 2. (Photo)cytotoxicity (IC50, μM) of the tested compounds toward A549, A549cisR and LO2 cells.
| Compound | A549 |
A549cisR |
LO2 |
|||
| Dark a (light) b | PI c | Dark a (light) b | PI c | Dark a (light) b | PI c | |
| 1 | 19.5 ± 2.1 (0.88 ± 0.08) | 22.2 | 18.2 ± 1.6 (0.37 ± 0.05) | 49.2 | 24.4 ± 1.8 (9.8 ± 1.1) | 2.5 |
| 2 | >100 (0.12 ± 0.03) | >833 | >100 (0.16 ± 0.03) | >625 | >100 (4.4 ± 0.7) | 22.7 |
| 3 | 29.9 ± 2.8 (1.2 ± 0.2) | 24.9 | 16.1 ± 1.2 (0.47 ± 0.03) | 34.3 | 68.7 ± 5.2 (13.4 ± 2.2) | 5.1 |
| 4 | 55.6 ± 4.1 (0.81 ± 0.09) | 68.6 | 59.4 ± 4.1 (0.14 ± 0.02) | 424 | 87.7 ± 6.7 (10.3 ± 1.4) | 8.5 |
| L1 | >100 (17.6 ± 1.9) | >5.7 | 42.6 ± 3.8 (19.7 ± 1.7) | 2.2 | >100 (47.4 ± 6.1) | >2.1 |
| L2 | >100 (>100) | — | >100 (>100) | — | >100 (>100) | — |
| Ir2(ppy)4Cl2 | 19.6 ± 2.6 (11.4 ± 1.4) | 1.7 | 20.2 ± 2.3 (7.0 ± 0.5) | 2.9 | 28.5 ± 2.4 (21.3 ± 1.6) | 1.3 |
| Ir2(dfppy)4Cl2 | 11.5 ± 1.5 (9.3 ± 1.0) | 1.2 | 4.3 ± 0.5 (4.2 ± 0.4) | 1.0 | 29.6 ± 3.1 (21.5 ± 2.7) | 1.4 |
| Cisplatin | 23.3 ± 2.6 (22.6 ± 2.9) | 1.0 | 85.5 ± 5.3 (86.1 ± 6.2) | 1.0 | 31.2 ± 2.7 (30.5 ± 3.1) | 1.0 |
aCells were incubated with the indicated compounds for 48 h.
bCells were incubated with the indicated compounds for 12 h and then irradiated with a 425 nm LED light array for 15 min (36 J cm–2).
cPI (phototoxicity index) is the ratio of the IC50 value in the dark to that obtained upon light irradiation.