Table 1.
RNA binding domains, the target mRNAs and associated disease
| RBP | RBDs | RNA recognized | Associated disease |
|---|---|---|---|
| LARP1 | 1× RRM, 1× La motif | mRNA (TOP‐mRNA) | Tumorigenesis (Lung, ovarian cancer) |
| PABP | 4× RRM | Poly(A) RNA | Oculopharyngeal muscular dystrophy, tumorigenesis (Breast, ovarian, CRC) |
| TIA‐1/TIAR | 3× RRM | mRNA | Tumorigenesis (tumor suppressors) |
| PKR | 2× dsRBD | dsRNA | Neurodegenerative disease (Huntington, Alzheimer's disease) |
| PTB | 4× RRM | pre‐mRNA, mRNA | Tumorigenesis (Breast, ovarian, CRC) |
| FMR1 | 2× KH‐domain | mRNA | Fragile X syndrome |
| Nucleolin | 4× RRM | pre‐rRNA, rRNA, mRNA | Tumorigenesis |
| HuR | 3× RRM | mRNA | Hu syndrome |