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. 2018 Feb 19;28(5):315–326. doi: 10.1002/hipo.22833

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© 2018 The Authors. Hippocampus Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Immediate early gene mRNA expression is increased in the lower blade of the dentate gyrus after landmark cue exploration. The dentate gyrus upper blade is unaffected. Bar charts summarize the immediate early gene mRNA expression in the upper and lower blade of the dentate gyrus. (a) Novel exploration of spatially arranged landmark cues increases Arc mRNA expression in the lower blade of the dentate gyrus but not in the upper blade (b). This latter effect was further verified by scrutinizing Homer1a mRNA expression (c,d). Here, novel landmark exploration triggered increased Homer1a mRNA expression in the lower (c) but not the upper blade (d) of the dentate gyrus. One way ANOVA: *p < .05; **p < .01. (e–h) Images show Arc mRNA (red points, indicated by white arrows) and Homer1a mRNA (green points, indicated by white arrows) expression in the lower blade and upper blade of the dentate gyrus. Blue: nuclear staining with DAPI. Images were taken using 63× objective. Scale bar: 10 μm [Color figure can be viewed at http://wileyonlinelibrary.com]