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. 2018 Feb 26;74(Pt 3):156–160. doi: 10.1107/S2053230X18002108

Figure 3.

Figure 3

The structure of Mnk1-KR in complex with DS12881479. (a) DS12881479 covered with an F o − F c OMIT electron-density map shown as a pink mesh contoured at 2.5σ. The bound DS12881479 and the residues within 4 Å of DS12881479 are shown in stick representation. The C atoms of the DFD motif (residues 191–193) and the activation segment (residues 194–235) of Mnk1-KR are coloured orange and dark green, respectively. Those of DS12881479 are coloured green. (b) A ribbon representation of Mnk1-KR complexed with DS12881479. DS12881479 is depicted as a CPK model. The side chain of Phe230 is shown in stick representation. The colour scheme is the same as that used in (a).