Table 2. R _free values for models after molecular replacement and after the automated CRANK2 pipelines.

	Molecular-replacement solution†	Substructure-only pipeline‡	Rebuild pipeline‡
Data set 1	49.8	32.6	29.8
Data set 2	53.7	28.9	32.3
GPCR ECR–Mb	48.6	39.1	38.4
AAA-ATPase	47.5	39.0	40.9
F1-ATPase	46.5	34.8	33.8
SecYEG–SecA	51.8	39.9	39.6

^†The R _free values after REFMAC5 ‘jelly-body’ refinement of the molecular-replacement solution using 50, 75 or 100 refinement cycles, whichever provided the best value.

^‡The R _free values after REFMAC5 ‘jelly-body’ refinement of the model output by CRANK2 using an additional 0, 25 or 50 refinement cycles, whichever provided the best value.