Indicator	Definition	Notes
Proportion of complete cases	Proportion of randomised participants for whom all data were available for the primary cost‐effectiveness analysis	If the number of complete‐cases was not clearly reported, we estimated an “upper bound,” from information, such as the proportion of participants with complete cost, or effect, data. See definition of primary analysis below.
Proportion complete effectiveness data	Proportion of randomised participants for whom all effectiveness data were Available for the primary cost‐effectiveness analysis	Same as above
Proportion complete cost data	Proportion of randomised participants for whom all cost data were available for the primary cost‐effectiveness analysis	Same as above
Report exact number of complete cases	Whether the number of participants with complete cost and effectiveness data was clearly reported.
More missing costs or effectiveness	Whether the proportion of complete cases differ between cost and effectiveness variable.	Considered “similar” when the proportion of complete cases was within 5% of each other.
Primary analysis method	Methods used to address missing data in the primary (base case) cost‐effectiveness analysis	When multiple effectiveness measures, time‐frames, or cost perspectives were reported, without a base‐case clearly defined, we considered the analysis based on quality‐adjusted life years (QALYs) over the longest within‐trial follow‐up period, from the NHS and social services cost perceptive.
Conducted a sensitivity analysis to missing data	Report results under more than one approach for addressing missing data