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. Author manuscript; available in PMC: 2019 Apr 23.
Published in final edited form as: Dev Cell. 2018 Apr 23;45(2):153–169.e6. doi: 10.1016/j.devcel.2018.03.019

Figure 7. Model of Lats kinase regulation of subepicardial cell differentiation and coronary vessel patterning.

Figure 7

In presence of Lats (Hippo kinases on), epicardial cells undergo EMT and transform into subepicardial mesenchyme. Subepicardial mesenchymal cells migrate and differentiate into cardiac fibroblasts (upper left). In absence of Lats (Hippo kinases off), epicardial cells undergo EMT and transform into subepicardium. Differentiation from subepicardium to cardiac fibroblasts is impaired (bottom left). In epicardial and subepicardial cells (middle and right), Lats1/2 kinases restrict nuclear Yap that is required for proper Dhrs3 activity. Nuclear Yap controls ECM composition and coronary patterning by matricellular factor regulation.