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. Author manuscript; available in PMC: 2018 May 11.
Published in final edited form as: Cell Rep. 2018 Apr 10;23(2):442–458. doi: 10.1016/j.celrep.2018.03.067

Figure 6. FOXF1 Regulates CDH2-CDH11 Cadherin Switching in Human IPF Lung Fibroblasts.

Figure 6

(A and B) CDH2 (A) and CDH11 (B) mRNA data using fibroblasts isolated from human IPF and normal lung samples obtained from GEO: GSE44723, GSE17978, and GSE1724. Data presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 by Student’s t test.

(C and D) Lung sections from normal human lung donors and IPF patients costained with αSMA and CDH2 (C) or CDH11 (D). Representative images are shown. IPF samples are n = 7, and normal lung samples are n = 6. Scale bars indicate 20 μm.

(E) Western blot analysis demonstrated decreased FOXF1 and CDH2 but increased CDH11 protein in human IPF compared to normal lungs.