Table 2. In silico analysis of toxicological properties of EPIIS predicted using the pkCSM methodology.
Model name | Unit | Preferred | EPIIS |
---|---|---|---|
Max. tolerated dose (human) | log mg/kg/day | < 0.477 | 0.451 |
hERG I inhibitor | - | No | No |
hERG II inhibitor | - | No | Yes |
Hepatotoxicity | - | No | Yes |
Skin sensitization | - | No | No |