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. 2018 May 11;13(5):e0196667. doi: 10.1371/journal.pone.0196667

Table 2. In silico analysis of toxicological properties of EPIIS predicted using the pkCSM methodology.

Model name Unit Preferred EPIIS
Max. tolerated dose (human) log mg/kg/day < 0.477 0.451
hERG I inhibitor - No No
hERG II inhibitor - No Yes
Hepatotoxicity - No Yes
Skin sensitization - No No