Table 4.
Effect of LBWon insulin resistance and beta cell function with mediation of established biomarkers
| Variable | Proportion mediated (% of total effect)
|
|
|---|---|---|
| Insulin resistance | Beta cell function | |
| Leptin and leptin receptor | ||
| Leptin | 15 | 58 |
| Soluble leptin receptor | 12 | 37 |
| Sex steroids and SHBG | ||
| Total oestradiol | 0 | 1 |
| Free oestradiol | –a | – |
| Total testosterone | – | – |
| Free testosterone | 6 | – |
| SHBG | 33 | 6 |
| Inflammation | ||
| TNFα-R2 | 2 | 0 |
| IL-6 | 2 | 1 |
| hsCRP | 2 | 1 |
| Endothelial function | ||
| E-selectin | 28 | 4 |
| ICAM-1 | – | 0 |
| VCAM-1 | 0 | 4 |
| Cellular ageing | ||
| Leucocyte telomere length | – | – |
| Blood pressure | ||
| Systolic | 13 | 10 |
| Diastolic | 7 | 9 |
a
Proportion mediated is undefined because the point estimate of the mediated effect is not in the same direction as the total effect