Table 2.

Association between BMI and dementia risk after serial adjustments for potential confounders at baseline and exclusion of the first 20 years of follow-up^∗

Adjustment in addition to age, sex, and ethnicity	Hazard ratio per 5 kg/m2 increase in BMI (95% confidence interval)	P value
None	1.17 (1.07–1.22)	.0003
Education/socioeconomic status	1.15 (1.06–1.24)	.0005
Smoking	1.17 (1.08–1.27)	<.0001
Cardiometabolic disease†	1.17 (1.07–1.27)	.0003
All the above	1.16 (1.07–1.25)	.0005

Abbreviation: BMI, body mass index.

^∗These analyses are based on eight studies with a follow-up longer than 20 years and data on covariates (total N = 147,581–147,893 depending on the model).

^†Prevalent coronary heart disease, stroke, or diabetes at baseline.