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. Author manuscript; available in PMC: 2018 Dec 6.
Published in final edited form as: Neuron. 2017 Dec 6;96(5):1024–1032.e3. doi: 10.1016/j.neuron.2017.11.013

Figure 3. Induced ApoE4 Expression in Astrocytes Impairs ISF Aβ Clearance in the Hippocampus of APP/PS1 Mice.

Figure 3

The ISF Aβ40 levels in APP/PS1 mice expressing apoE3 (A-B, APP/iE3; n=8/group) or apoE4 (C–D, APP/iE4; n=4/group) at the age of 3–4 months were analyzed. To assess Aβ40 half-life, the mice were treated with a γ-secretase inhibitor, and the hippocampal ISF Aβ40 levels were monitored. The slope from the individual linear regressions from log (% ISF Aβ40) versus time for each mouse was used to calculate the mean half-life (t1/2) of elimination for Aβ from the ISF (B, D). Data represent mean ± SEM. *, p<0.05; N.S., not significant.