Table 3.

Factors associated with removal of the NES/EE CVR for >2 hours (non-adherence)

	Total (905) N	Ring remover (120) n (%)	OR*	95% CI	P value
Education					0.01
College	344	32 (9.3)	ref	-
Some college	227	24 (10.6)	1.12	0.61 – 2.06
High school	248	39 (15.7)	1.69	0.91 – 3.14
Grade school	86	25 (29.1)	3.23	1.55 – 6.75
Study region					0.003
US	286	37 (12.9)	ref	-
Latin America	290	62 (21.4)	1.15	0.65 – 2.02
Europe	270	20 (7.4)	0.44	0.24 – 0.83
Australia	59	1 (1.7)	0.13	0.02 – 0.98
Ring is easy to insert					0.005
Yes	834	107 (12.8)	ref	-
No	65	13 (20)	2.80	1.36 – 5.80
Remove ring before sex					<0.001
No	677	64 (9.4)	ref	-
Yes	220	56 (25.4)	3.19	2.03 – 4.99
Remove ring to wash it					<0.001
No	540	32 (5.9)	ref	-
Yes	352	88 (25)	3.96	2.50 – 6.27

NES/EE CVR: Nestorone®/ethinyl estradiol contraceptive vaginal ring

N: number of participants in each category; n (%): number and percentage of ring removers in each category

^*OR based on a multivariate model including the variables shown