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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Cytotherapy. 2018 Mar 16;20(5):650–659. doi: 10.1016/j.jcyt.2018.02.369

Figure 3. OCT inhibition impairs UC-MSC-4 cellular uptake of metformin and downregulates metformin-induced AMPK activation.

Figure 3

(A) Metformin uptake assay performed in UC-MSC-4 cells to analyze OCT-dependent metformin uptake in the presence or absence of the pan-OCT inhibitor quinidine. OCT inhibition significantly impaired the uptake of 10 μM [14C]-metformin. (B) Whole cell extracts from UC-MSC-4 cells exposed to metformin for 3 hours in the presence or absence of quinidine were subjected to Western blotting. β-actin served as loading control.