Figure 1.

Monoexponential support data. (a) Plot of the sampling time T for accurately determining $\tilde{\mathbf{A}}$ when k varies from $\widehat{\mathit{k}}$. (b) Plot of the optimal sampling time T _OPT as a function of the averaging interval. T _OPT is determined by integrating Eq. (5) over the interval 1 − α to 1 + α. The plot indicates that over a relatively large range, T _OPT  ≈ $\widehat{\tau }$. (c) Plot of the error in the estimated total integrated activity as a function of the error in the estimated rate constant. Large variations in k from $\widehat{\mathit{k}}$ have a relatively small effect on the accuracy of ${\tilde{\mathbf{A}}}^{\ast }$ over a wide range. [Color figure can be viewed at wileyonlinelibrary.com]