This work is licensed under a Table 1.
Summary of biochemical investigations and HR-pQCT parameters.
| Value | RR or centile* | |
|---|---|---|
| Biochemical investigations | ||
| HbA1c (%) | 7.8% | ≤6.0 |
| Creatinine (µmol/L) | 96 | 60–105 |
| Urea (mmol/L) | 4.4 | 4.4–9.0 |
| Estimated GFR (mL/min/1.73 m2) | >90 | >90 |
| Alkaline phosphatase (U/L) | 136 | 42–135 |
| Corrected calcium (mmol/L) | 2.49 | 2.14–2.50 |
| Magnesium (mmol/L) | 0.90 | 0.66–1.07 |
| Phosphate (mmol/L) | 0.65 | 0.60–1.30 |
| Parathyroid hormone (pmol/L) | 4.5 | 1.6–6.9 |
| Vitamin D (nmol/L) | 28 | >50 |
| TSH (mU/L) | 1.60 | 0.3–5.00 |
| FSH (U/L) | 2.8 | 1.4–13.6 |
| Luteinising hormone (U/L) | 1.0 | 0.6–12.1 |
| Total testosterone (nmol/L) | 20.6 | 8.0–30.0 |
| Prolactin (U/L) | 218 | 73–306 |
| Cortisol, post ODST (nmol/L) | 42 | <50 |
| Transglutaminase AB (U/mL) | 0 | 0–4 |
| Gliadin IgA (units) | 5 | 0–19 |
| Gliadin IgG (units) | 2 | 0–19 |
| Tryptase (µg/L) | 4.1 | 0.0–11.4 |
| Serum protein electrophoresis | NPD | |
| CTX (ng/L) | 1435 | 400–900 |
| P1NP (µg/L) | 151 | 15–115 |
| HR-pQCT) parameters | ||
| Radius | ||
| Total BMD (mg/HA/cm3) | 274.2 | <10th |
| Cortical BMD (mg/HA/cm3) | 792.3 | <10th |
| Trabecular BMD (mg/HA/cm3) | 177.0 | <25th |
| Trabecular number (1/mm) | 1.67 | <10th |
| Trabecular thickness (mm) | 0.088 | 75th |
| Trabecular separation (mm) | 0.511 | 90th |
| Cortical thickness (mm) | 0.62 | <10th |
| Tibia | ||
| Total BMD (mg/HA/cm3) | 246.3 | <10th |
| Cortical BMD (mg/HA/cm3) | 835.0 | <10th |
| Trabecular BMD (mg/HA/cm3) | 172.1 | <10th |
| Trabecular number (1/mm) | 1.87 | 25th |
| Trabecular thickness (mm) | 0.077 | 10th |
| Trabecular separation (mm) | 0.459 | 75th |
| Cortical thickness (mm) | 0.82 | <10th |
Abnormal values are denoted in bold.
*RR is presented for biochemical investigations and centiles for HR-pQCT parameters. Centiles are derived from age-, sex- and site-specific centile curves for HR-pQCT parameters using a Canadian reference population from the study by Burt et al. (1).
BMD, bone mineral density; CTX, C-terminal telopeptide; GFR, glomerular filtration rate; HA, hydroxyapatite; HR-pQCT, high-resolution peripheral quantitative computed tomography; NPD, no paraprotein detected; ODST, overnight dexamethasone suppression test; P1NP, N-terminal propeptide of type 1 collagen; RR, reference range; HbA1c, glycated haemoglobin; TSH, thyroid stimulating hormone; FSH, follicle stimulating hormone; AB, antibodies.