Table 2.
The association between clinical histopathological features of OSCC and expression of PRC1
| Factors | Number (n) | Positive rate | Intensity | Staining score | p value |
|---|---|---|---|---|---|
| Sex | |||||
| Male | 37 | 82.14 ± 8.23 | 2.68 ± 0.48 | 217.86 ± 33.48 | 0.881 |
| Female | 17 | 83.59 ± 7.57 | 2.64 ± 0.49 | 219.41 ± 34.75 | |
| Age (years) | |||||
| ≤60 | 31 | 83.18 ± 7.76 | 2.64 ± 0.49 | 218.18 ± 37.45 | 0.930 |
| >60 | 23 | 82.55 ± 8.11 | 2.68 ± 0.48 | 219.09 ± 30.44 | |
| Location | |||||
| Buccal | 10 | 80.30 ± 8.59 | 2.80 ± 0.42 | 223.20 ± 33.62 | 0.936 |
| Tongue | 16 | 83.13 ± 8.19 | 2.60 ± 0.51 | 214.20 ± 35.46 | |
| Gingival | 12 | 82.25 ± 8.00 | 2.63 ± 0.52 | 214.38 ± 32.94 | |
| Floor of oral | 12 | 86.25 ± 7.82 | 2.63 ± 0.52 | 225.13 ± 35.59 | |
| Others | 4 | 82.67 ± 2.08 | 2.67 ± 0.58 | 219.67 ± 43.04 | |
| Differentiation | |||||
| Well | 31 | 83.74 ± 7.74 | 2.44 ± 0.51 | 202.41 ± 32.49 | 0.003* |
| Moderate | 16 | 81.73 ± 7.12 | 2.87 ± 0.35 | 234.07 ± 27.29 | |
| Poor | 7 | 80.20 ± 9.66 | 3.00 ± 0.00 | 240.60 ± 28.96 | |
| T stage | |||||
| T1 | 20 | 82.06 ± 8.21 | 2.41 ± 0.51 | 194.53 ± 25.52 | 0.003* |
| T2 | 10 | 82.60 ± 8.10 | 2.80 ± 0.42 | 230.20 ± 31.84 | |
| T3 | 8 | 86.46 ± 5.94 | 2.55 ± 0.52 | 219.364 ± 39.45 | |
| T4 | 16 | 79.56 ± 7.44 | 3.00 ± 0.00 | 239.67 ± 22.38 | |
| N (lymph node metastasis) | |||||
| N0 | 28 | 82.41 ± 8.29 | 2.82 ± 0.40 | 231.50 ± 29.26 | 0.004* |
| N1N2 | 26 | 83.00 ± 7.27 | 2.48 ± 0.51 | 203.44 ± 33.49 | |
| Clinical stage | |||||
| I/II | 33 | 82.19 ± 7.74 | 2.55 ± 0.51 | 206.71 ± 31.39 | 0.005* |
| III/IV | 21 | 83.75 ± 7.72 | 2.81 ± 0.40 | 235.69 ± 32.35 |
No statistical difference between PRC1 and sex, age, tumor location was found in patients with OSCC. However, increased PRC1 was significantly associated with poor differentiation, large tumor volume, lymph node metastasis and high-clinical stage (p < 0.05). Error bars, mean ± SD (n ≥ 4); *p < 0.05; t-test or Wilcoxon rank sum test.