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. 2018 May 11;9(5):563. doi: 10.1038/s41419-018-0582-1

Fig. 5. The role of lncRNA-PRLB as a tumor promoter in breast cancer was partially reversed by miR-4766-5p.

Fig. 5

a LncRNA-PRLB expression was analyzed in MDA-MB-231, MDA-MB-468, or MCF7 cells transfected with pcDNA3.1-PRLB or control simultaneously with mimics of miR-4766-5p or NC. b MTT assays were used to determine the cell proliferation for pcDNA3.1-PRLB and miR-4766-5p mimics co-transfected MDA-MB-231, MDA-MB-468 and MCF7 cells. c MTT assays were used to determine the sensitivity to 5-FU in MDA-MB-231, MDA-MB-468, and MCF7 cells co-transfected with pcDNA3.1-PRLB and miR-4766-5p mimics. d 5-FU of 50 μg/ml was used to test the inhibition of drug resistance caused by pcDNA3.1-PRLB and miR-4766-5p mimics co-transfection in MDA-MB-231, MDA-MB-468, and MCF7 cells. e Transwell migration assays were used to determine the cell metastasis for pcDNA3.1-PRLB and miR-4766-5p mimics co-transfected MDA-MB-231 and MDA-MB-468 cells. *P < 0.05, **P < 0.01, and ***P < 0.001