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. 2018 May 11;9(5):562. doi: 10.1038/s41419-018-0631-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — FOXM1 and UHRF1 protein expression levels were analyzed in 546 prostate cancer tumor tissues using the TCGA data. The prostate cancer tumors were subclassified in three grades by Gleason score (low: 1–4, middle: 5–7, and high 8–10). a FOXM1 and UHRF1 expression levels were up-regulated as Gleason scores increased. b FOXM1 and UHRF1 protein levels showed a strong positive correlation in prostate cancer tissues (R = 0.6927). c FOXM1 and UHRF1 expression showed a high correlation in prostate cancer cells and normal prostate epithelial cells. d FOXM1 maintains CSC characteristics by regulating UHRF1. FOXM1 was depleted with a small molecule inhibitor, siomycin A, and UHRF1 was elevated by transient transfection. The expression levels of CSC-associated molecules ALDH1, SOX2, and SHH were tested by Western blot. e The depletion of FOXM1 with siRNA in CNE2TR and DU145-DR cells decreased the mRNA and protein levels of UHRF1. f The upregulation of FOXM1 in CNE2 and DU145 cells elevated the UHRF1 levels