Table 2.
NAb and IgG Titers to AAV2 and AAV8 in Adults and Children
| Subject ID No. | Age Group | NAb Titer (Reciprocal Dilution, 1:x) |
IgG (μg/mL) |
||
|---|---|---|---|---|---|
| AAV2 | AAV8 | AAV2 | AAV8 | ||
| Ad-58 | adult | <1:1 | <1:1 | 0.0 | 3.7 |
| Ad-56 | adult | 1:1 | <1:1 | 4.4 | 3.1 |
| Ad-105 | adult | 1:1 | <1:1 | 7.6 | 6.5 |
| Ad-32 | adult | 1:1 | <1:1 | 3.7 | 7.2 |
| Ad-89 | adult | 1:1 | <1:1 | 81.2 | 17.7 |
| Ad-109 | adult | 1:100 | <1:1 | 1.5 | 5.6 |
| Ad-118 | adult | <1:1 | <1:1 | 0.3 | 2.2 |
| Ad-93 | adult | 1:3.16 | <1:1 | 6.6 | 4.8 |
| Ad-101 | adult | 1:10 | 1:1 | 29.0 | 12.0 |
| Ad-21 | adult | 1:1 | 1:1 | 8.7 | 6.1 |
| Ch-1 | child | 1:3.16 | <1:1 | 0.58 | 0.41 |
| Ch-2 | child | <1:1 | <1:1 | 0.72 | 0.73 |
| Ch-3 | child | <1:1 | <1:1 | 2.01 | 1.47 |
| Ch-4 | child | 1:1 | <1:1 | 0.13 | 0.23 |
| Ch-5 | child | <1:1 | <1:1 | 0.07 | 0.15 |
| Ch-6 | child | 1:3.16 | <1:1 | 0.05 | 0.07 |
| Ch-7 | child | 1:1 | 1:1 | 0.2 | 1.10 |
| Ch-8 | child | 1:1 | <1:1 | 0.07 | 0.18 |
| Ch-9 | child | <1:1 | <1:1 | 0.25 | 0.34 |
| Ch-10 | child | <1:1 | <1:1 | 0.02 | 0.54 |
| Ch-11 | child | 1:1 | <1:1 | ND | 0.08 |
ND, not determined