Table 1.

The effect of Aβ42 oligomers and PARP1 inhibitor on the level of mRNA of DNA bound PARPs

Gene	mRNA level of DNA bound PARPs/Actb [% of control]
	Aβ	PJ-34	Aβ + PJ-34
Parp1	120.6 ± 9.10	106.40 ± 2.75	115.10 ± 0.95
Parp2	109.40 ± 5.31	100.40 ± 3.96	109.30 ± 6.23
Parp3	98.94 ± 5.60	118.5 ± 0.70*	130.00 ± 5.82*

PC12 cells were incubated in the presence of oligomeric Aβ42 (AβO, 1 μM) and PJ-34 (20 μM) for 24 h. The levels of mRNA of DNA bound PARPs—Parp1, Parp2, and Parp3—were analyzed via quantitative RT-PCR. The results of RT-PCR were normalized to Actb gene expression. Data represent the mean value ± SEM for three independent experiments with three replications. *p < 0.05—the difference, that was statistically significant compared to the control cells, using one-way analysis of variance (ANOVA) with Neuman-Keuls post hoc test