Fig. 1.

The administration of S1RA diminishes ischaemic brain damage. a Representative brain section images were obtained from saline- (left) and S1RA-treated mice (3 nmol/mouse, 1 h after surgery; right) 48 h after pMCAO using MRI (BIOSPEC BMT 47/40). b The bar graphs quantitatively compare the infarct volume (±SEM) from the saline- (white bars) and S1RA-treated mice (grey bars) at different time intervals before and after surgery. Groups consisted of 8–10 mice, and the data are represented as the means ± SEMs. Asterisk indicates the significant difference from saline-treated mice, degrees of freedom (df) = 16, all pairwise Holm-Sidak multiple comparison tests following ANOVA, p < 0.05