Fig. 1.

Statistical maps depicting brain areas in which the gray matter intensity covaried with a six target seeds, b seed volume comparisons, and c structural covariance networks (Z-statistic maps [p < 0.01, corrected with a false discovery rate with extended cluster voxels >100]) in all patients with Alzheimer’s disease with the catechol-O-methyltransferase Val158Met polymorphism (Met-carriers, n = 91; Val-homozygote carriers, n = 101). A significantly lower dorsal caudal putamen gray matter seed volume was found in the Met-carriers (p < 0.05). The images were displayed on a standard brain render