Table 1.

Demographical characteristics and neuropsychiatric tests in the COMT genotype groups in 192 Alzheimer’s disease

Genotype group	Met-carriers (n = 91)	Val/Val (n = 101)	p value
Age	73.3 ± 8.6	73.9 ± 7.2	0.62
Education (year)	7.3 ± 4.9	7.4 ± 4.9	0.91
Apolipoprotein E4 carrier (positive case, %)	32, 35.16%	34, 33.66%	0.88
Sex (male/female)	43/48	52/49	0.56
MMSE	19.9 ± 6.36	19.6 ± 6.81	0.772
Clinical dementia rating sum of box	3.6 ± 3.02	4.0 ± 3.22	0.375
Mental manipulation	6.0 ± 3.30	4.7 ± 3.18	0.008
Attention	6.3 ± 1.44	6.0 ± 1.63	0.202
Orientation	12.6 ± 5.23	12.5 ± 5.31	0.821
Long-term memory	8.2 ± 2.96	7.9 ± 2.72	0.497
Short-term memory	4.9 ± 3.87	5.6 ± 3.92	0.199
Abstract thinking	8.2 ± 2.91	7.9 ± 2.77	0.398
Drawing	7.7 ± 2.91	7.6 ± 3.06	0.797
Verbal fluency	5.1 ± 2.69	4.9 ± 2.87	0.663
Language	8.1 ± 2.20	7.9 ± 2.44	0.528
Executive function test	25.5 ± 8.17	23.5 ± 8.41	0.507
Total scores of CASI	67.2 ± 21.85	65.1 ± 22.26	0.510
Neuropsychiatric inventory scores total	8.49 ± 13.45	7.89 ± 9.99	0.723
Delusion	0.84 ± 2.32	0.54 ± 1.81	0.332
Hallucination	0.31 ± 1.18	0.01 ± 0.10	0.012
Aggression	0.53 ± 2.03	0.25 ± 1.03	0.223
Depression	1.15 ± 2.70	1.23 ± 2.59	0.847
Anxiety	0.35 ± 1.48	0.44 ± 1.48	0.695
Elation	0.08 ± 0.52	0.01 ± 0.10	0.207
Apathy	0.77 ± 2.50	0.88 ± 2.74	0.769
Disinhibition	0.11 ± 0.75	0.36 ± 1.75	0.216
Irritability	1.12 ± 2.41	0.98 ± 2.02	0.661
Aberrant motor behavior	0.42 ± 1.75	0.39 ± 1.73	0.901
Sleep disorders	2.45 ± 4.42	2.10 ± 4.12	0.569
Eating behavior	0.37 ± 1.28	0.71 ± 2.02	0.171

Data are presented as mean (standard deviation) or number (percentage; %); attention, verbal fluency, abstract thinking, and mental manipulation sub-domain scores of the CASI were added to assess executive function; APOE4 carriers were defined as the presence of one or two APOE4 alleles. The italicized word represents scores showing significance

CASI cognitive ability screening instrument, COMT catechol-O-methyltransferase