Table 3.
Significant correlations between peak cluster volumes and neurobehavioral test scores in the COMT Met-carriers
| Seed region | PCC | Dorsal caudal putamen | Dorsal rostral putamen | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Peak cluster | Superior medial frontal | Superior occipital | Middle occipital | Superior parietal | Postcentral | Caudate | Angular | Middle occipital | Paracentral lobule | Caudate | SMA | Postcentral |
| Mini-Mental State Examination | 0.15 | 0.16 | 0.42** | 0.18 | 0.27* | −0.14 | 0.20 | 0.43** | −0.06 | 0.22* | 0.03 | 0.25* |
| CASI total scores | 0.11 | 0.19 | 0.45** | 0.19 | 0.24* | −0.14 | 0.24* | 0.47** | −0.07 | 0.19 | −0.01 | 0.20 |
| CASI EFT scores | 0.11 | 0.20 | 0.42** | 0.16 | 0.21* | −0.14 | 0.26* | 0.42** | −0.07 | 0.20 | 0.02 | 0.17 |
| Short-term memory | 0.14 | 0.00 | 0.26* | 0.12 | 0.13 | −0.27* | 0.01 | 0.30** | −0.17 | 0.08 | −0.08 | 0.04 |
| Orientation | 0.09 | 0.20 | 0.41** | 0.21* | 0.19 | −0.10 | 0.25* | 0.43** | −0.03 | 0.11 | −0.06 | 0.18 |
| Long-term memory | 0.06 | 0.21* | 0.48** | 0.20 | 0.26* | −0.04 | 0.25* | 0.48** | 0.01 | 0.22* | 0.04 | 0.25* |
| Language | 0.09 | 0.08 | 0.37** | 0.12 | 0.26* | −0.11 | 0.10 | 0.38** | 0.01 | 0.21* | −0.02 | 0.21 |
| Drawing | 0.13 | 0.19 | 0.32** | 0.10 | 0.21* | 0.00 | 0.22* | 0.35** | −0.09 | 0.17 | 0.08 | 0.24* |
| Attention | 0.11 | 0.23* | 0.36** | 0.17 | 0.22* | −0.03 | 0.23* | 0.35** | 0.13 | 0.22* | 0.15 | 0.20 |
| Verbal fluency | 0.01 | 0.13 | 0.29* | 0.13 | 0.11 | −0.13 | 0.16 | 0.25* | −0.05 | 0.16 | −0.05 | 0.06 |
| Abstract thinking | 0.08 | 0.17 | 0.41** | 0.12 | 0.21 | −0.16 | 0.24* | 0.44** | −0.02 | 0.23* | −0.01 | 0.14 |
| Mental manipulation | 0.07 | 0.15 | 0.31* | 0.10 | 0.17 | −0.09 | 0.21* | 0.31** | −0.17 | 0.07 | 0.03 | 0.16 |
| Hallucination | −0.04 | −0.15 | −0.20 | 0.00 | −0.07 | 0.00 | −0.16 | −0.20 | 0.26* | −0.07 | 0.15 | −0.13 |
| Anxiety | 0–0.134 | −0.02 | 0.21* | 0.15 | −0.03 | −0.06 | −0.05 | 0.19 | 0.04 | −0.01 | −0.10 | −0.09 |
| Elation | −0.067 | −0.17 | −0.20 | 0.10 | −0.10 | 0.03 | −0.17 | −0.24* | 0.03 | −0.11 | 0.02 | −0.10 |
| Apathy | −0.087 | −0.23* | −0.29** | −0.06 | −0.17 | −0.03 | −0.21* | −0.29** | 0.14 | −0.14 | 0.04 | −0.04 |
| Aberrant motor behavior | −0.129 | −0.13 | −0.20 | 0.01 | −0.22* | −0.04 | −0.12 | −0.23* | 0.03 | −0.22* | −0.04 | −0.14 |
| Eating behavior | −0.073 | −0.13 | −0.06 | 0.11 | 0.09 | 0.21* | −0.20 | −0.07 | 0.19 | 0.09 | 0.10 | −0.02 |
Selected peak clusters indicate structural covariance strength showing Met-carriers > Val-homozygotes
PCC posterior cingulate cortex, SMA supplementary motor area, COMT catechol-O-methytransferase
Numbers indicate Pearson’s correlation coefficients—*p < 0.05; **p < 0.01