Table 3.
HLA-G genotype frequencies in women depending on the severity of endometriosis
| Genotype | E I + II (%) | E III + IV (%) | E III + IV vs E I + II | ||||||
|---|---|---|---|---|---|---|---|---|---|
| P | OR | 95% CI | Test for independence | Test for trend | |||||
| p | χ2 | p | χ2 | ||||||
| rs371194629:ins/del | N = 16 | N = 187 | |||||||
| Del/del* | 8 (50.00) | 62 (33.16) | 1 | 0.24 | 2.89 | 0.52 | 0.41 | ||
| Ins/del | 4 (25.00) | 87 (46.52) | 0.13 | 2.81 | (0.81–9.74) | ||||
| Ins/ins | 4 (25.00) | 38 (20.32) | 1.00 | 1.23 | (0.35–4.35) | ||||
| Minor allele ins | 12 (37.50) | 163 (43.58) | |||||||
| rs1632947:G>A | N = 16 | N = 187 | |||||||
| AA* | 2 (12.50) | 56 (29.95) | 1 | 0.05 | 5.86 | 0.022 | 5.26 | ||
| AG | 6 (37.50) | 87 (46.52) | 0.71 | 0.52 | (0.10–2.66) | ||||
| GG | 8 (50.00) | 44 (23.53) | 0.04 a | 0.20 | (0.04–0.97) | ||||
| Minor allele A | 10 (31.25) | 199 (53.21) | |||||||
| rs1233334:G>C/T | N = 16 | N = 187 | |||||||
| CC* | 8 (50.00) | 132 (70.59) | 1 | 0.05 | 9.27 | 0.013 | 6.15 | ||
| CG | 5 (31.25) | 44 (23.53) | 0.33 | 0.53 | (0.17–1.72) | ||||
| GG | 1 (6.25) | 5 (2.67) | 0.32 | 0.30 | (0.03–2.91) | ||||
| GT | 0 (0.00) | 3 (1.60) | 1.00 | 0.45 | (0.02–9.43) | ||||
| CT | 2 (12.50) | 3 (1.60) | 0.04 b | 0.09 | (0.01–0.62) | ||||
| TT | 0 (0.00) | 0 (0.00) | |||||||
| Minor allele T | 2 (6.25) | 6 (1.60) | |||||||
E I + II endometriosis I + II, E III + IV endometriosis III + IV, P probability, OR odds ratio, 95% CI 95% confidence interval from two-sided Fisher’s exact test, χ 2 df = 2 p Chi-square test for independence with two degrees of freedom for the 14 bp ins/del (rs371194629:insATTTGTTCATGCCT/del) in 3′UTR and rs1632947:G>A polymorphisms, χ 2 df = 4 p Chi-square test for independence with four degrees of freedom for the polymorphism rs1233334:G>C/T, χ 2 df = 1 p Chi-square test for trend with one degree of freedom for all tested polymorphisms; *Reference
a P corr. = 0.12
b P corr. = 0.12