Table 4.
HLA-G genotype frequencies in women from endometriosis groups depending on the localization of lesions
| Genotype | Endometriosis peritoneal only | Endometriosis ovarian only | Endometriosis ovarian + peritoneal | Endometriosis peritoneal only vs endometriosis ovarian only | Endometriosis peritoneal only vs endometriosis ovarian + peritoneal | Endometriosis ovarian only vs endometriosis ovarian + peritoneal | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P | OR | 95% CI | Test for independence | P | OR | 95% CI | Test for independence | P | OR | 95% CI | Test for independence | |||||||
| p | χ2 | p | χ2 | p | χ2 | |||||||||||||
| rs371194629:ins/del | N = 16 | N = 136 | N = 92 | |||||||||||||||
| Del/del* | 8 (50.00) | 43 (31.62) | 34 (36.95) | 1 | 0.23 | 2.97 | 1 | 0.38 | 1.94 | 1 | 0.70 | 0.72 | ||||||
| Ins/del | 4 (25.00) | 30 (22.06) | 18 (19.57) | 0.76 | 1.40 | (0.38–5.06) | 1.00 | 1.06 | (0.28-4.00) | 0.57 | 0.76 | (0.36–1.59) | ||||||
| Ins/ins | 4 (25.00) | 63 (46.32) | 40 (43.48) | 0.12 | 2.93 | (0.83–10.35) | 0.22 | 2.35 | (0.65–8.50) | 0.54 | 0.80 | (0.44–1.46) | ||||||
| Minor allele ins | 12 (37.50) | 156 (57.35) | 98 (53.26) | |||||||||||||||
| rs1632947:G>A | N = 16 | N = 136 | N = 92 | |||||||||||||||
| AA* | 2 (12.50) | 44 (32.35) | 26 (28.26) | 1 | 0.042 | 6.33 | 1 | 0.28 | 2.57 | 1 | 0.29 | 2.49 | ||||||
| AG | 7 (43.75) | 67 (49.26) | 41 (44.57) | 0.48 | 0.44 | (0.90–2.19) | 0.47 | 0.45 | (0.09–2.34) | 1.00 | 1.04 | (0.56–1.93) | ||||||
| GG | 7 (43.75) | 25 (18.38) | 25 (27.17) | 0.028 a | 0.16 | (0.03–0.84) | 0.15 | 0.27 | (0.05–1.45) | 0.19 | 1.69 | (0.81–3.54) | ||||||
| Minor allele A | 11 (34.38) | 155 (56.99) | 129 (47.43) | |||||||||||||||
| rs1233334:G>C/T | N = 16 | N = 136 | N = 92 | |||||||||||||||
| CC* | 7 (43.75) | 101 (74.26) | 64 (69.57) | 1 | 0.07 | 8.80 | 1 | 0.006 | 14.35 | 1 | 0.29 | 5.02 | ||||||
| CG | 6 (37.50) | 28 (20.59) | 23 (25.00) | 0.08 | 0.32 | (0.10–1.04) | 0.19 | 0.42 | (0.13–1.38) | 0.51 | 1.30 | (0.69–2.45) | ||||||
| GG | 1 (6.25) | 2 (1.47) | 3 (3.26) | 0.20 | 0.14 | (0.01–1.72) | 0.37 | 0.33 | (0.03–3.60) | 0.38 | 2.37 | (0.38–14.56) | ||||||
| GT | 0 (0.00) | 1 (0.74) | 2 (2.17) | 1.00 | 0.22 | (0.01–5.93) | 1.00 | 0.58 | (0.03–13.30) | 0.56 | 3.16 | (0.28–35.54) | ||||||
| CT | 2 (12.50) | 4 (2.94) | 0 (0.00) | 0.07 | 0.14 | (0.02–0.89) | 0.01 b | 0.02 | (0.001–0.53) | 0.30 | 0.17 | (0.01–3.30) | ||||||
| TT | 0 (0.00) | 0 (0.00) | 0 (0.00) | – | – | – | – | – | – | – | – | – | ||||||
| Minor allele T | 2 (6.25) | 5 (1.84) | 2 (1.09) | |||||||||||||||
P probability, OR odds ratio, 95% CI 95% confidence interval from two-sided Fisher’s exact test, χ 2 df = 2 p Chi-square test for independence with two degrees of freedom for the 14 bp ins/del (rs371194629:ins ATTTGTTCATGCCT/del) in 3′UTR and rs1632947:G>A polymorphisms, χ 2 df = 4 p Chi-square test for independence with four degrees of freedom for the polymorphism of the rs1233334:G>C/T
*Reference
a P corr. = 0.08
b P corr. = 0.03