Table 5.
LILRB1, LILRB2 and KIR2DL4 genotype and minor allele frequencies in women from Control and Endometriosis groups
| Genotype | Control (%) | Patients (%) | Patients vs Control | ||||
|---|---|---|---|---|---|---|---|
| P | OR | 95% CI | Test for independence | ||||
| p | χ2 | ||||||
| LILRB1 rs41308748:G>A | N = 314 | N = 272 | |||||
| GG* | 261 (83.12) | 226 (83.09) | 1 | 0.0035 | 11.33 | ||
| GA | 49 (15.61) | 30 (11.03) | 0.18 | 0.71 | (0.43–1.15) | ||
| AA | 4 (1.27) | 16 (5.88) | 0.0048 a | 4.62 | (1.52–14.02) | ||
| Minor allele A | 57 (9.08) | 62 (11.40) | |||||
| H-W | 0.33 | 0.00 | |||||
| LILRB1 rs1061680:T>C | N = 314 | N = 272 | |||||
| TT* | 191 (60.82) | 176 (64.71) | 1 | 0.14 | 3.88 | ||
| TC | 112 (35.67) | 80 (29.41) | 0.18 | 0.76 | (0.54–1.10) | ||
| CC | 11 (3.51) | 16 (5.88) | 0.32 | 1.58 | (0.71–3.50) | ||
| Minor allele C | 134 (21.34) | 112 (20.59) | |||||
| H-W | 0.27 | 0.097 | |||||
| LILRB2 rs383369:G>A | N = 314 | N = 272 | |||||
| AA* | 226 (71.97) | 186 (68.38) | 1 | 0.23 | 2.91 | ||
| AG | 82 (26.12) | 84 (30.88) | 0.27 | 1.25 | (0.87–1.79) | ||
| GG | 6 (1.91) | 2 (0.74) | 0.31 | 0.41 | (0.08–2.03) | ||
| Minor allele G | 94 (14.97) | 88 (16.18) | |||||
| H-W | 0.65 | 0.022 | |||||
| LILRB2 rs7247538:C>T | N = 314 | N = 272 | |||||
| TT* | 107 (34.08) | 94 (34.56) | 1 | 0.58 | 1.10 | ||
| CT | 146 (46.50) | 134 (49.26) | 0.85 | 1.05 | (0.73–1.50) | ||
| CC | 61 (19.42) | 44 (16.18) | 0.47 | 0.82 | (0.51–1.32) | ||
| Minor allele C | 268 (42.68) | 222 (40.81) | |||||
| H-W | 0.38 | 0.74 | |||||
| KIR2DL4 rs649216:T>C | N = 314 | N = 276 | |||||
| TT* | 103 (32.80) | 93 (33.70) | 1 | 0.26 | 2.70 | ||
| CT | 150 (47.77) | 116 (42.03) | 0.45 | 0.86 | (0.59–1.24) | ||
| CC | 61 (19.43) | 67 (24.28) | 0.42 | 1.22 | (0.78–1.90) | ||
| Minor allele C | 272 (43.31) | 250 (45.29) | |||||
| H-W | 0.63 | 0.012 | |||||
H–W Hardy–Weinberg equilibrium, P probability, OR odds ratio, 95% CI 95% confidence interval from two-sided Fisher’s exact test, χ 2 df = 2 p Chi-square test for independence with two degrees of freedom for all tested polymorphisms; For four samples from the endometriosis group we could not perform LILRB1 and LILRB2 genotyping because of a lack of DNA
*Reference
a P corr. = 0.024