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. 2018 Mar 12;144(6):1025–1035. doi: 10.1007/s00432-018-2625-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Effect of MLL2 knockout on cell proliferation in Eca109. a, b MTT assay and colony formation assay showed that knockout of MLL2 significantly reduced the proliferation ability of Eca109 cells. c Effect of MLL2 knockout on cell cycle in Eca109. Knockout of MLL2 arrested cell cycle at G1 phase. d Effect of MLL2 knockout on cell apoptosis. Knockout of MLL2 did not significantly affected cell apoptosis in Eca109 (P > 0.05). NC, negative control. KO, MLL2 knockout group. *P < 0.05, **P < 0.01